Our Projects

Project #1: Cervical length

A survey presented at the ESPBC in Gothenburg 2016 showed there is much variation across European countries in screening and diagnosing spontaneous preterm birth and cut-offs used for cervical length.


The aim of this project is to:

  • Standardize how to measure cervical length
  • Assess if it is possible to have a universal cervical length cut-off 
  • Standardize the definition of at risk population for preterm birth


Responsible: Dr. Frederik Hermans

Project #2: Biomarkers

The ESPBC Gothenburg 2016 survey also showed there is much variation in how the diagnosis of threatening preterm birth is made: based on cervical length? based on a biomarker? based on the combination?
The aim of this project is to assess which test for preterm birth has the best prognostic accuracy. The group is writing a systematic review and doing a meta-analysis on the prognostic accuracy of commercially available bedside biomarker tests for preterm labour. The review is registered on PROSPERO (CRD42018092628).


Responsible: Dr. Isabelle Dehaene

Project #3: Infections

The goal is to make an inventory of the various screening and treatment strategies that are performed in the field of infections and preterm birth.


The aim of this project is to make a comparison between what is advised in the different national guidelines and what is done in daily practice (with the help of an international survey among I-SPY members).


Responsible: Dr. Brenda Kazemier

Project #4: Risk factor | Core demographics

Using an umbrella systematic review, this group first aims to provide a field-wide meta-analysis of risk factors for preterm birth. For each putative risk factor four meta-analyses will be done using univariate only, multivariate only, preferentially univariate, or preferentially multivariate estimates. Putting the results together this wil result in a so called ‘risk factor heat map’ (a map of all reported OR and their 95% CI). This overview can then be used to develop a ‘core baseline set’ for all studies on preterm birth, to be sure that future studies take into account potential confounders and effect modifiers.


Responsible: Dr. Janneke van 't Hooft

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